抗性糊精/桑叶提取物降血糖功效的系统评价与Meta分析

发布时间：2026-04-13 浏览量：

作者

孙萌朱晓丹

DOI

10.65700/RH-GJXZYXYJ2026.111.697

年，卷(期)

2026-01

摘要：目的探讨抗性糊精/桑叶提取物的降血糖功效。方法系统检索数据库中抗性糊精、桑叶提取物与血糖管理相关临床研究，提取关键指标数据，进行Meta分析。结果共纳入21项研究，其中抗性糊精8篇，桑叶提取物13篇。结果显示，抗性糊精干预后FBG[SMD=-0.67，95%CI（-0.86，-0.48），P＜0.00001]及胰岛素抵抗指数（HOMA-IR）[MD=-3.05，95%CI（-3.36，-2.74），P＜0.00001]均较治疗前下降。同时，抗性糊精干预后空腹血糖（FBG）[SMD=-0.91，95% CI（-1.73，-0.09），P=0.03]及糖化血红蛋白（HbA1c）[MD=-0.45，95% CI（-0.89，-0.01），P=0.04]水平均低于对照。与治疗前及对照相比，桑叶提取物干预后均显著降低 FBG[SMD=-1.12，95% CI（-1.81，-0.44），P=0.001；SMD=-0.68，95% CI（-1.21，-0.15），P=0.01]、餐后2h血糖（2hPG）[SMD=-1.59，95% CI（-3.03，-0.41），P=0.03；SMD=-1.01，95% CI（-1.52，-0.49），P=0.001]、及 HbA1c [MD=-0.64，95% CI（-1.04，-0.24），P=0.002；MD=-0.31，95% CI（-0.61，-0.01），P=0.04]水平。结论现有研究证据表明，膳食中补充抗性糊精或桑叶提取物在改善血糖方面均有显著效果。

关键词：抗性糊精；桑叶提取物；血糖；糖尿病；Meta 分析

Abstract:Objective To investigate the hypoglycemic effect of resistance dextrin（RD）/mulberry leaf extract（MLE）. Methods Systematically search the databases for clinical studies related to RD，MLE and blood glucose management，extract key indicator data，and conduct Meta-analysis.Result A total of 21 studies were included，among which 8 were related to RD and 13 were related to MLE. The analysis results showed that after the intervention with RD，FBG [SMD=-0.67，95% CI（-0.86，-0.48），P<0.00001]，and [HOMA-IR（MD=-3.05，95%CI（-3.36，-2.74），P<0.00001]were lower than those before treatment. Meanwhile，after the intervention with RD，FBG [SMD=-0.91，95%CI（-1.73，-0.09），P=0.03]，and HbA1c [MD=-0.45，95%CI（-0.89，-0.01），P=0.04] were lower than those of the control group. Compared with the pre-treatment and the control group，the intervention of MLE significantly reduced the levels of FBG [SMD = -1.12，95% CI（-1.81，-0.44），P = 0.001；SMD = -0.68，95% CI（-1.21，-0.15），P = 0.01]，2hPG [SMD = -1.59，95% CI（-3.03，-0.41），P = 0.03；SMD = -1.01，95% CI（-1.52，-0.49），P = 0.001]，and HbA1c [MD = -0.64，95% CI（-1.04，-0.24），P = 0.002；MD = -0.31，95% CI（-0.61，-0.01），P = 0.04]. Conclusion The current research evidence indicates that supplementing the diet with RD or MLE can both significantly improve blood sugar levels.

Key words:resistance dextrin；mulberry leaf extract；blood glucose；diabetes；Meta-analysis