以全蝎与蜈蚣为主成分的外用膏剂的功效评价:随机对照试验的系统评价与Meta分析

摘要:目的 评价以全蝎/娱蚣为主成分的外用膏剂的临床疗效。方法 计算机检索医学数据库，收集相关随机对照试验，采用RevMan5.3软件进行Meta分析。结果 总共采集25篇文献，共计1734例患者。Meta分析显示:在周围血管病治疗中，试验组对糖尿病足及下肢静脉溃疡的治疗有效率显著高于对照组[OR=4.97,95%CI(2.23，11.06),P<0.0001;OR=5.39，95%CI(2.22,13.12),P-0.0002]，且创面面积、肉芽形态、渗出及疼痛等指标均显著改善。在皮肤病治疗中，试验组的有效率及治愈率均显著高于对照组[OR=3.14,95%CI(1.80，5.47),P<0.0001; OR=3.55, 95%CI (2.23, 5.66),P<0.00001];银屑病患者的PASI 量表评分于对照组[MD=-2.08,95%CI (-2.90, -1.25), P<0.00001]显著减少。在外伤性疾病治疗中，试验组的有效率及治愈率显著优于对照组[OR-6.89,95%CI(2.66,17.84),P<0.0001;OR=3.67,95%CI(2.10,6.41),P0.00001]。在干燥性鼻炎治疗中，试验组有效率亦显著高于对照组[OR=2.38,95%CI (1.28,4.44)，P-0.006]。结论 以全蝎/娱蚣为主成分的外用膏剂在周围血管病、皮肤病、外伤性疾病及干燥性鼻炎的治疗中均显著提高临床有效率，安全性高，证实其治疗功效。

关键词:全蝎;蜈蚣;外用膏剂;功效评价;Meta分析

Abstract: Objective To evaluate the clinical efficacy of topical ointments with whole scorpion and centipede as the main ingredients. Methods Medical databases were scarched to collect relevant randomnized controlled trials, and a meta -analysis was performed using RevMan 5.3 sofitware.Results A25 articles involving 1734 patients were included. The meta-analysis showed that in the treatment of peripheral vascular diseases, theeffective rate of the experimental group for diabetic foot and venous uleers of the lower extrenities was significanly higher than that of the controlgroup [OR-4.97, 95%C (2.23, 11.06), P0.0001; OR-5.39, 95%CI (2.2, 13.12), P-0.0002], and indicators such as wound area, granulationmophology, exudation, and pain were significantly improved. In the treatment of skin diseases, the effective rate and cure rate of the experimentalgroup were significantdly higher than those of the control group [OR-3.14,9%CI(1.80,5.47), P<0.0001; OR-3.55,95%CI(2.3,5.66), P<0.00001];the PASI score of psoriasis patients was significantly lower than that of the control group [MD--2.08, 95%CI (-2.90, -1.25), P0.000011. In thetrcatment of traumatic discases, the cffective rate and cure cxperimental group were significanly better than those of the control group [OR-6.8995%CI(2.6, 17.84), P<0.0001; OR-3.67,95%CI(2.10, 6.1), P0.0001] In the treatment of atrphic thinitis, the effective rate of the experinentalgroup was also significantly higher than that of the control group [OR-2.38,95%CI(1.28, 4.44),P-0.006]. Conclusion Topical ointmcnts with wholeion a wer extrenities was significanly higher than that of the controlgroup [OR-4.97, 95%C (2.23, 11.06), P0.0001; OR-5.39, 95%CI (2.2, 13.12), P-0.0002], and indicators such as wound area, granulationmophology, exudation, and pain were significantly improved. In the treatment of skin diseases, the effective rate and cure rate of the experimentalgroup were significantdly higher than those of the control group [OR-3.14,9%CI(1.80,5.47), P<0.0001; OR-3.55,95%CI(2.3,5.66), P<0.00001];the PASI score of psoriasis patients was significantly lower than that of the control group [MD--2.08, 95%CI (-2.90, -1.25), P0.000011. In thetrcatment of traumatic discases, the cffective rate and cure cxperimental group were significanly better than those of the control group [OR-6.8995%CI(2.6, 17.84), P<0.0001; nd centipede as the main ingredients significantly improve clinical efficacy in the treatnent of peripheral vascular diseases, skin diseases,traumatic diseases, and atrophic rhinitis, with high safety and therapeutic efficacy.

Key words: Scorpion; Scolopendra; External ointment; Efficacy evaluation; Meta-analysis