白芸豆提取物减肥功效的系统评价与Meta分析

摘要：目的 系统评价白芸豆提取物对超重/肥胖人群减重减脂的应用效果。方法 使用医学数据库进行文献检索，挖掘相关原始研究，进行 Meta 分析。结果 纳入 11 项人体临床研究，结果显示，与对照组相比，白芸豆提取物可有效降低体重[MD=-2.30，95%CI（-2.84，-1.76），P＜0.00001]，体重指数（BMI）[MD=-0.81，95%CI（-1.02，-0.60），P＜0.00001]、腰围[MD=-2.10，95%CI（-2.62，-1.58），P＜0.00001]、臀围[MD=-1.43，95%CI（-2.45，-0.40），P=0.007]、大腿围[MD=-1.02，95%CI（-1.65，-0.38），P=0.002]、体脂[SMD=-0.68，95%CI（-0.89，-0.46），P＜0.00001]及脂肪量[MD=-2.17，95%CI（-2.42，-1.92），P＜0.00001]，差异有统计学意义。结论 现有证据表明，补充白芸豆提取物对超重/肥胖人群的体重、BMI、腰围、臀围、大腿围、体脂及脂肪量的影响均具有统计学意义，这为其减重减脂的临床应用提供循证证据支撑。 

关键词：白芸豆提取物；减重；减脂；Meta 分析

Abstract：Objective To systematically evaluate the application effect of white kidney bean extract on weight loss and fat reduction in overweight/obese individuals. Methods A systematic literature search，was performed using medical databases to retrieve relevant original studies and review articles，followed by Meta-analysis. Results A total of 11 human clinical studies were included. Compared with the control group，the results showed that white kidney bean extract significantly reduced body weight [MD = -2.30，95%CI：-2.84 to -1.76，P < 0.00001]，BMI[MD = -0.81，95%CI：-1.02 to -0.60，P < 0.00001]，waist circumference[MD = -2.10，95%CI：-2.62 to -1.58，P < 0.00001]，hip circumference [MD = -1.43，95%CI：-2.45 to -0.40，P = 0.007]，thigh circumference [MD = -1.02，95%CI：-1.65 to -0.38，P = 0.002]，body fat percentage [SMD = -0.68，95%CI：-0.89 to -0.46，P < 0.00001]，and fat mass [MD = -2.17，95%CI：-2.42 to -1.92，P < 0.00001]. All differences were statistically significant. Conclusion Current evidence indicates that supplementation with white kidney bean extract significantly improves body weight，BMI，waist circumference，hip circumference，thigh circumference，body fat percentage，and fat mass of overweight/obese individuals，and providing evidence-based support for its clinical application in weight loss and fat reduction.

 Key words：White kidney bean extract；Weight loss；Fat reduction；Meta-analysis